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You are about to embark on an amazing journey of discovery. Th e study of life spans from the inner workings of cells to the complex interactions of entire ecosystems, through the information stored in DNA to the ways genetic information evolves over time. At the same time that our understanding of biology is growing in leaps and bounds, so too are great insights into how learners acquire new knowledge and skills. We are thrilled to join Scott Freeman on Biological Science, a book dedicated to active, research-based learning and to exploring the experimental evidence that informs what we know about biology. Th e next few pages highlight the features in this book and in MasteringBiology® that will help you succeed. From left to right: Michael Black, Emily Taylor, Jon Monroe, Lizabeth Allison, From left to right: Michael Black, Emily Taylor, Jon Monroe, Lizabeth Allison, Greg Podgorski, Kim Quillin
Supports and motivates you as you learn to think scientifically and use the skills of a biologist. Scott Freeman's Biological Science is beloved for its Socratic narrative style, its emphasis on experimental evidence, and its dedication to active learning. In the Fifth Edition, the author team has expanded to include new members --bringing a fresh focus on accuracy and currency, and multiplying the dedication to active learning by six. Research indicates that true mastery of content requires a move away from memorization towards active engagement with the material in a focused, personal way. Biological Science is the first introductory biology text designed to equip you with a strategy to accurately assess your level of understanding, predict your performance, and identify the types of cognitive skills that need improvement. Package consists of: Biological Science, Volume 1, Fifth Edition
In many respects,w e understand the structure of the universeb etter than the workings of living cells. Scientists can calculate the age of the Sun and predict when it will cease to shine, but we cannot explain how it is that a human being may live for eighty years but a mouse for only two. We know the complete genomes equenceso f thesea nd many other speciesb, ut we still cannot predict how a cell will behave if we mutate a previously unstudied gene. Stars may be l0a3 times bigger, but cells are more complex, more intricately structured, and more astonishingp roducts of the laws of physicsa nd chemistry.T hrough heredity and natural selection, operating from the beginnings of life on Earth to the presentd ay-that is, for about 20Voo f the ageo f the universe-living cellsh ave been progressively refining and extending their molecular machinery and recording the results of their experiments in the genetic instructions they pass on to their progeny. With each edition of this book, we marvel at the new information that cell biologists have gathered in just a few years. But we are even more amazed and daunted at the sophistication of the mechanisms that we encounter. The deeper we probe into the cell,t he more we reafizeh ow much remainst o be understood. In the days of our innocence, working on the first edition, we hailed the identification of a single protein-a signal receptol say-as a great step forward' Now we appreciate that each protein is generally part of a complexwith many others, working together as a system, regulating one another's activities in subtle ways, and held in specific positions by binding to scaffold proteins that give the chemical factory a definite spatial structure. Genome sequencing has given us virtually complete molecular parts-lists for many different organisms; genetics and biochemistry have told us a great deal about what those parts are capable of individually and which ones interact with which others; but we have only the most primitive grasp of the dynamics of these biochemical systems, with all their interlocking control loops. Therefore, although there are great achievements to report, cell biologistsf ace eveng reaterc hallengesf or the future. In this edition, we have included new material on many topics, ranging from epigeneticsh, istonem odificationss, mall RNAs,a nd comparativeg enomicst,o geneticn oise,c ytoskeletadl lmamics,c ell-cyclec ontrol, apoptosis,s tem cells, and novel cancer therapies. As in previous editions, we have tried above all to give readers a conceptual framework for the mass of information that we now have about cells. This means going beyond the recitation of facts. The goal is to learn how to put the facts to use-to reason, to predict, and to control the behavior of living systems. To help readers on the way to an active understanding, we have for the first time incorporatede nd-of-chapterp roblems,w ritten by Iohn Wilson and Tim Hunt. These emphasize a quantitative approach and the art of reasoning from experiments.A companion volume, MolecularB iologyo f the CelI,F ifth Edition: TheP roblemsB ook0 SBN9 78-0-8153-4110-9b)y, t he samea uthors,g ivesc omplete answerst o thesep roblemsa nd alsoc ontainsm ore than 1700a dditional problems and solutions. A further major adjunct to the main book is the attached Media DVD-ROM disc. This provides hundreds of movies and animations, including manythat are new in this edition, showing cells and cellular processesin action and bringing the text to life; the disc also now includes all the figures and tables from the main book,p re-loadedin to [email protected] esentationsO. thera ncillariesa vailablefo r the book include a bank of test questions and lecture outlines, available to qualified instructors,a nd a seto f 200f ull-coloro verheadtr ansparencies. Perhaps the biggest change is in the physical structure of the book. In an effort to make the standard Student Edition somewhat more portable, we are providing chapters 2r-25, covering multicellular systems, in electronic (pDF) form on the accompanying disc, while retaining in the printed volume chapters l-20, covering the core of the usual cell biology curriculum. But we should emphasize that the final chapters have been revised and updated as thoroughly as the rest of the book and we sincerely hope that they will be read! A Reference Edition (ISBN9 7s-0-8153-4r11-6c)o, ntainingt he full seto f chaptersa sp rinred pages, is also available for those who prefer it. Full details of the conventions adopted in the book are given in the Note to the Readert hat follows this PrefaceA. s explainedt here,w e have taken a drastic approach in confronting the different rules for the writing of gene names in different species: throughout this book, we use the same style, regardless of speciesa, nd often in defianceo fthe usuals pecies-specifcico nventions. As always,w e are indebted to many people. Full acknowledgmentsfo r scientific help are given separatelyb, ut we must here singleo ut somee xceptionally important contributions: Iulie Theriot is almost entirely responsible for chapters 16 (cytoskeleton)a nd 24 (PathogensI,n fection, and Innate Immunity), and David Morgan likewise for chapter 17 (cell cycle). wallace Marshall and Laura Attardi provided substantialh elp with chapters 8 and 20, respectively,a s did Maynardo lson for the genomicss ectiono f chapter4 ,X iaodongwangf or chapter 18, and Nicholas Harberd for the plant section of Chapter 15. we also owe a huge debt to the staff of Garland science and others who helped convert writers' efforts into a polished final product. Denise schanck directed the whole enterprise and shepherded the wayward authors along the road with wisdom, skill, and kindness. Nigel orme put the artwork into its final form and supervisedt he visuala spectso f the book,i ncluding the backc over,w ith his usual flair. Matthew Mcclements designed the book and its front cover. Emma Jeffcockla id out its pagesw ith extraordinarys peeda nd unflappablee fficiency, d ealingi mpeccablywith innumerablec orrections.M ichaelM oralesm anaged the transformation of a mass of animations, video clips, and other materials into a user-friendly DVD-ROM. Eleanor Lawrence and sherry Granum updatedand enlargedt he glossaryJ. ackieH arbor and SigridM assonk ept us organized. Adam Sendroffkept us aware ofour readers and their needs and reactions. Marjorie Anderson, Bruce Goatly, and sherry Granum combed the text for obscurities, infelicities, and errors. we thank them all, not only for their professional skill and dedication and for efficiency far surpassing our own, but also for their unfailing helpftrlnessa nd friendship:t hey havem adei t a pleasuret o work on the book. Lastly, and with no less gratitude, we thank our spouses, families, friends and colleaguesw. ithout their patient,e ndurings upport,w e couldn ot havep roduced any of the editions of this book. MolecularB iologyo f the Cell BruceA lberts AlexandeJro hnson JulianL ewis Martin Raff Keith Roberts PeteWr alter Withp roblemsb y John Wilson Tim Hunt GarlandS cience Taylo&r FranciGs roup
Reflecting the broad and interdisciplinary nature of toxicology, this third edition of Principles of Toxicology explores the biochemical, physiological, and environmental aspects of the subject. This new edition is updated and revised to include reference to several major new directions in the science of toxicology, including significant changes in thinking about cancer and carcinogenesis as well as the rapid expansion of toxicogenomics. The book also includes new chapters on topics of timely interest such as radiation, food safety, and natural toxins. As in previous editions, chapters combine background material in the appropriate discipline—which helps readers review and remember the basics—with new information on toxicology to stress key principles and concepts. Also included is a selection of updated case studies through which principles and concepts are applied to real-world issues. The book features an extensive cross-referencing system linking all sections and enhancing the integration of material, thus helping readers tie it all together. It also includes an appendix of selected toxicants that describes chemical structure, category of use, and toxicity. These features make specific information quick and easy to find. The easy-to-follow format and clear presentation of information in this book will make this one of the most useful references on your shelf.
This text presents mathematical biology as a field with a unity of its own, rather than only the intrusion of one science into another. The book focuses on problems of contemporary interest, such as cancer, genetics, and the rapidly growing field of genomics.
Biological Science Fundamentals and Systematics is a component of Encyclopedia of Biological, Physiological and Health Sciences in the global Encyclopedia of Life Support Systems (EOLSS), which is an integrated compendium of twenty one Encyclopedias. The Theme on Biological Science Fundamentals and Systematics provides the essential aspects and a myriad of issues of great relevance to our world such as: History and Scope of Biological Sciences; The Origin and Evolution of Early Life; Evolution; Classification and Diversity of Life Forms; Systematics of Microbial Kingdom (s) and Fungi; Systematic Botany; Systematic Zoology: Invertebrates; Systematic Zoology: Vertebrates which are then expanded into multiple subtopics, each as a chapter. These four volumes are aimed at the following five major target audiences: University and College students Educators, Professional practitioners, Research personnel and Policy analysts, managers, and decision makers and NGOs.
Not every book merits a fifth edition! An invaluable resource, this thorough and detailed guide will enable anyone charged with grantseeking to submit winning proposals. • Offers advanced writing tips highlighting technological tools that will help writers work smarter, not harder, to increase proposal persuasiveness • Includes an expanded presentation of logic models that graphically display the relationship between situation, processes, and resulting outputs and outcomes • Features a new chapter on sustainability, complete with sample language to help grantseekers answer the dreaded question, "How will your project be sustained beyond the granting period?" • Shares practical tips that have enabled the authors to write winning grants for four decades

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