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Genomics research has made significant advances in recent years. In this book, a team of internationally-renowned researchers share the most up-to-date information in a field that has in recent years switched emphasis from gene identification to functional genomics and the characterization of genes and gene products. This volume approaches this complex subject with a broad perspective to supply the reader with a vital overview of genomics and its derivative fields, with a focus on pivotal issues such as data analysis. Expansive and current, this book is a comprehensive research guide that describes both the key new techniques and more established methods. Every chapter discusses the merits and limitations of the various approaches and then provides selected tried-and-tested protocols, as well as a plethora of good practical advice for immediate use at the bench. Key features: Provides a broad introduction to current practices and techniques for lab-based research in genomics Explains clearly and precisely how to carry out selected techniques in addition to background information on the various approaches Chapters are written by a leading international authorities in the field and cover both well-known and new, tried and tested, methods for working in genomics Includes troubleshooting guide and reviews of alternative techniques An essential laboratory manual for students and researchers at all levels
This Updated 7th edition features a new section, Genetic Control, at the end of the text. This section complements Cummings' coverage with a series of cases from noted medical ethicist, Dr. Ronald Munson, which investigate the issues surrounding the stem-cell debate, genetic counseling, genetic testing and reproductive decisions, and gene therapy. These cases are reinforced with original readings from other noted geneticists, ethicists, and medical policy makers. The result is a text that will draw students into the most current research in genetics and educate them on the latest challenges facing physicians, researchers, and society. Instructors will find this Seventh Edition of HUMAN HEREDITY current, clear, and complemented by an amazing array of technology for students and instructors. Additional student support includes Human GeneticsNow, a password-protected website integrated with the Seventh Edition that provides students with access to diagnostic Pre-Tests and Post-Tests for each chapter. It automatically generates customized learning plans for students, directing them to text information and ancillaries that help them master specific concepts. Active Figures in the text, indicated by a media icon, have corresponding narrated animations on the Human GeneticsNow site that are included in the customized Learning Plan along with additional animations and media assets. For instructors, a Multimedia Manager provides all of the art and photos from the text in PowerPoint form, and, lectures can be further enhanced by using animations and videos on human heredity topics. Important Notice: Media content referenced within the product description or the product text may not be available in the ebook version.
Psychiatrists and other mental health professionals are increasingly confronted with questions about the genetics of psychiatric illness, and the clinical applications of new genetic findings. Psychiatric Genetics: A Primer for Clinical and Basic Scientists addresses these questions through a straightforward introduction to the essentials of psychiatric genetics, complementing more comprehensive textbooks that may seem overwhelming for those new to the field. Written and edited by leaders in the field and the International Society of Psychiatric Genetics (ISPG), the book covers basic epidemiology, recruitment for human studies, phenotyping strategies, formal genetic and molecular genetic studies, statistical genetics, bioinformatics and genomics, pharmacogenetics, the most relevant animal models, and biobanking. Each chapter begins with a list of "take home" points that summarizes content, followed by a brief overview of current knowledge and suggestions for further reading. This Primer is ideal for medical students, psychiatric residents, psychiatrists, and basic neuroscience researchers who are interested in learning about the key concepts and recent advances in the exciting field of psychiatric genetics.
This book covers the statistical models and methods that are used to understand human genetics, following the historical and recent developments of human genetics. Starting with Mendel’s first experiments to genome-wide association studies, the book describes how genetic information can be incorporated into statistical models to discover disease genes. All commonly used approaches in statistical genetics (e.g. aggregation analysis, segregation, linkage analysis, etc), are used, but the focus of the book is modern approaches to association analysis. Numerous examples illustrate key points throughout the text, both of Mendelian and complex genetic disorders. The intended audience is statisticians, biostatisticians, epidemiologists and quantitatively- oriented geneticists and health scientists wanting to learn about statistical methods for genetic analysis, whether to better analyze genetic data, or to pursue research in methodology. A background in intermediate level statistical methods is required. The authors include few mathematical derivations, and the exercises provide problems for students with a broad range of skill levels. No background in genetics is assumed.
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