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Traditional toxicology textbooks tend to be doorstops: tomes filled with important but seemingly abstract chemistry and biology. Meanwhile, magazine and journal articles introduce students to timely topics such as BPA and endocrine disruption or the carcinogenic effects of pesticides, but don't provide the fundamentals needed to understand the science of toxicity. Written by a longtime professor of toxicology, Modern Poisons bridges this gap. This accessible book explains basic principles in plain language while illuminating the most important issues in contemporary toxicology. Kolok begins by exploring age-old precepts of the field such as the dose-response relationship and the concept, first introduced by Ambroise Paré in the sixteenth century, that a chemical's particular action depends on its inherent chemical nature. The author goes on to show exactly how chemicals enter the body and elicit their toxic effect, as well as the body's methods of defense. With the fundamentals established, Kolok digs into advances in toxicology, tracing the field's development from World War II to the present day. The book examines both technical discoveries and their impacts on public policy. Highlights include studies of endocrine-disrupting chemicals in toiletries and prescriptions, the emerging science on prions, and our growing understanding of epigenetics. Readers learnnot only how toxic exposure affects people and wildlife, but about the long-term social and environmental consequences of our chemicals. Whether studying toxicology itself, public health, or environmental science, readers will develop a core understanding of—and curiosity about—this fast-changing field.
Understanding Toxicology is a comprehensive study of toxicants and their impact on all levels of biology--from cell, to complex organism, to ecosystem. Unlike other texts of its kind, this text is uniquely structured by biological system, making it easy for readers to understand the impact of toxins on each system. Common mechanisms are explored in the cellular and complex organ system chapters to approach a systems biology perspective that is more applicable to modern computational toxicology risk assessment. Understanding Toxicology begins with three research questions that challenge the reader to discover what information is needed to solve controversies at the level of the cell, the complex organism, and the ecosystem. The book continues with a cellular, complex organism, and ecosystem analysis of toxicology principles including risk assessment. The cellular section follows common mechanisms from the outside to the inside of cells and individual organelles. A forensic approach analyzes complex organisms from outside to inside. The ecosystem section starts with a dispersion approach to determine environmental concentration and addresses toxicants in divisions similar to how the EPA determines impacts. Key Features • Uses lively, engaging examples making the text fun and easy to read and understand • Allows the reader to approach the subject from a research perspective as well as a public policy perspective • Covers biological toxicants including venoms, poisons, as well as microbial and fungal toxins, and plant toxins • Thoroughly covers all organisms including fish, plants, and microbes • Includes outlines and review questions in each chapter
This book provides an overview of historical and contemporary cases of homicidal poisoning. While homicidal poisoning is sometimes thought of as a thing of the past, it continues to be a contemporary problem, and in fact the unknown offender rate for poisoning cases is 20-30 times that of other homicide types in contemporary research, and many poisoners commit serial homicides while going undetected. The author of this important and timely work explores the theoretical bases for understanding homicidal poisoning, the nature of poisons used in homicidal cases, the characteristics of poisoners and their victims, and techniques for detection and prevention. This unique book will be of particular interest to: students of criminology (classes dealing with criminal psychology, and murder investigation); students of the history of crime; criminal justice professionals: attorneys, homicide detectives, forensic pathologists, forensic and clinical toxicologists, and other forensic investigators; and all interested in poisons, poisoners and the detection of poisoning. It has relevance to criminology, law and policing, toxicology and forensic science, the history of crime and detection, and criminal psychology.
Clarke's Analytical Forensic Toxicology offers a fresh perspective on the drugs and poisons that are most likely to be encountered in forensic toxicology. It focuses on collection, extraction and analysis. This second edition is fully updated to reflect advances in analytical and forensic toxicology. New and extended chapters include: sampling, storage and stability; in-utero exposure to drugs of abuse; drug-facilitated sexual assault; extraction. Additional features are included from the fourth edition of Clarke's Analysis of Drugs and Poisons.
Written as an advanced text for toxicology students, this book is much more than an introduction and provides in-depth information describing the underlying mechanisms through which toxicants produce their adverse responses. • Links traditional toxicology to modern molecular techniques, important for teaching to graduate courses and professional studies • Uses a didactic approach with basic biological or theoretical background for the methodology presented • Brings together and comprehensively covers a range of dynamic aspects in biochemical and molecular toxicology • Guides student and professional toxicologists in comprehending a broad range of issues, compiled and authored by a diverse group of experts • “A good introductory textbook covering the biochemical toxicology of organic substances and the relevant methodology in some detail.... It offers good value for money and can be recommended as a textbook for appropriate courses” – BTS Newsletter review of the 4th edition
A collection of challenging and unusual cases from the author's extensive experience as a Medical Toxicologist, these cases demonstrate medical problem solving and differential diagnosis in action from the perspective of an experienced clinician. Written in an engaging style and giving a fascinating account of some complex cases from real practice, this book will provide a good supplementary learning text for graduate students or those at an early stage in their professional career.
How can a plant as beautiful as the foxglove be so deadly and yet for more than a century be used to treat heart disease? The same is true of other naturally occurring molecules as will be revealed in this current book by award-winning author and chemist, John Emsley. More Molecules of Murder follows on from his highly-acclaimed earlier book Molecules of Murder, and again it deals with 14 potential poisons; seven of which are man-made and seven of which are natural. It investigates the crimes committed with them, not from the point of view of the murderers, their victims, or the detectives, but from the poison used. In so doing it throws new light on how these crimes were carried out and ultimately how the perpetrators were uncovered and brought to justice. Each chapter starts by looking at the target molecule itself, its discovery, its chemistry, its often-surprising use in medicine, its effects on the human body, and its toxicology. The rest of the chapter is devoted to murders and attempted murders in which it has been used. But, be reassured that murder by poison is not the threat it once was, thanks to laws which restrict access to such materials and to the skills of analytical chemists in detecting their presence in incredibly tiny amounts.

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