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The Physicochemical Basis of Pharmaceuticals explores the physical and chemical phenomena which affect the formulation and bio-availability of drug substances to give a straightforward, accessible treatment of the essential concepts affecting the absorption and distribution of drugs.
Taking medication is a common occurrence for many people, whether it is to soothe an aching head, regulate blood sugars, or to treat life threatening conditions, such as HIV or cancer. In the UK alone, over 900 million prescriptions are dispensed every year. Overseeing all of this are pharmacists: experts in medicines and their use. The Integrated Foundations of Pharmacy series supports those who are at the beginning of their journey to become a pharmacist. The reader will begin to understand how a drug molecule is made; the process that turns it into a medicine; the role the pharmacist has when dispensing that medicine; and what happens in the body when it is taken. Most importantly, the series shows how each of these aspects are integrated, reflecting the most up-to-date teaching practices. Pharmaceutics: the science of medicine design explores the different forms that medicines can take, and demonstrates how being able to select the best form - be it a tablet, injectable liquid, or an inhaled gas - requires an understanding of how chemicals behave in different physical states. Online Resource Centre The Online Resource Centre to accompany Pharmaceutics: the science of medicine design features: For registered adopters of the book: - Figures from the book, available to download. For students: - Self-assessment questions to help the reader to check and reinforce understanding of the material introduced in each chapter.
Florence and Attwood's well known textbook uses pharmaceutical examples to illustrate the underlying physical chemistry of drug characterisation, formulation, delivery, transport and adsorption. Students of pharmacology, toxicology, medicine and researchers will want this book.
Physical chemistry is the basis of rational pharmaceutical formulation and processing, and provides the basis for understanding the complexities of drug delivery and drug absorption. Knowledge of the physicochemical principles is essential for the modern pharmaceutical scientist and pharmacist. rewritten, updated and reset, while retaining its essential characteristic of using only pharmaceutical examples to illustrate the physical chemistry involved. A new chapter on proteins as pharmaceuticals is included. Solutions, the solid state and the gaseous state are discussed (the latter particularly with pressurised aerosols in mind), while ionization of drugs is considered at length. Surface chemistry retains its place and the treatment of colloidal systems includes discussion of liposomes and other colloidal carriers now more widely used in therapeutics. The properties of soluble, insoluble and dispersible natural and synthetic polymers - elements of many delivery systems - are described. physiology of the route and the conditions of the route that affect the drug and dosage form. Many drug interactions have a physicochemical basis and these are considered in a short chapter. In vitro functionality tests for many delivery systems can be devised if the physical basis of their functioning is recognised; again a short chapter deals with this important topic relating to the quality of pharmaceuticals. Wherever possible, calculations and worked examples are included to aid understanding of the equations described. There are many diagrams and each chapter contains a bibliography.
This 6th edition of the established textbook covers every aspect of drug properties from the design of dosage forms to their delivery by all routes to sites of action in the body.
Properties and Formulation: From Theory to Real-World Application Scientists have attributed more than 40 percent of the failures in new drug development to poor biopharmaceutical properties, particularly water insolubility. Issues surrounding water insolubility can postpone or completely derail important new drug development. Even the much-needed reformulation of currently marketed products can be significantly affected by these challenges. More recently it was reported that the percentage increased to 90% for the candidates of new chemical entities in the discovery stage and 75% for compounds under development. In the most comprehensive resource on the topic, this third edition of Water-Insoluble Drug Formulation brings together a distinguished team of experts to provide the scientific background and step-by-step guidance needed to deal with solubility issues in drug development. Twenty-three chapters systematically describe the detailed discussion on solubility theories, solubility prediction models, the aspects of preformulation, biopharmaceutics, pharmacokinetics, regulatory, and discovery support of water-insoluble drugs to various techniques used in developing delivery systems for water-insoluble drugs. This book includes more than 15 water-insoluble drug delivery systems or technologies, illustrated with case studies and featuring oral and parenteral applications. Highlighting the most current information and data available, this seminal volume reflects the significant progress that has been made in nearly all aspects of this field. The aim of this book is to provide a handy reference for pharmaceutical scientists in the handling of formulation issues related to water-insoluble drugs. In addition, this book may be useful to pharmacy and chemistry undergraduate students and pharmaceutical and biopharmaceutical graduate students to enhance their knowledge in the techniques of drug solubilization and dissolution enhancement.
Colloid and Interface Science in Pharmaceutical Research and Development describes the role of colloid and surface chemistry in the pharmaceutical sciences. It gives a detailed account of colloid theory, and explains physicochemical properties of the colloidal-pharmaceutical systems, and the methods for their measurement. The book starts with fundamentals in Part I, covering fundamental aspects of colloid and interface sciences as applied to pharmaceutical sciences and thus should be suitable for teaching. Parts II and III treat applications and measurements, and they explains the application of these properties and their influence and use for the development of new drugs. Provides a clear description of the fundamentals of colloid and interface science relevant to drug research and development Explains the physicochemical/colloidal basis of pharmaceutical science Lists modern experimental characterization techniques, provides analytical equations and explanations on analyzing the experimental data Describes the most advanced techniques, AFM (Atomic Force Microscopy), SFA (Surface Force Apparatus) in detail

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