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This book summarizes state-of-the-art antiviral drug design and discovery approaches starting from natural products to de novo design, and provides a timely update on recently approved antiviral drugs and compounds in advanced clinical development. Special attention is paid to viral infections with a high impact on the world population or highly relevant from the public health perspective (HIV, hepatitis C, influenza virus, etc.). In these chapters, limitations associated with adverse effects and emergence of drug resistance are discussed in detail. In addition to classical antiviral strategies, chapters will be dedicated to discuss the non-classical drug development strategies to block viral infection, for instance, allosteric inhibitors, covalent antiviral agents, or antiviral compounds targeting protein–protein interactions. Finally, current prospects for producing broad-spectrum antiviral inhibitors will be also addressed. The book is distinctive in providing the most recent update in the rapidly evolving field of antiviral therapeutics. Authoritative reviews are written by international scientists well known for their contributions in their topics of research, which makes this book suitable for researchers not only within the antiviral research community but also attractive to a broad audience in the drug discovery field. This book covers molecular structures and biochemical mechanisms mediating the antiviral effects, while discussing various ligand design strategies, which include traditional medicinal chemistry, computational chemistry, and chemical biology approaches. The book provides a comprehensive review of antiviral drug discovery and development approaches, particularly focusing on current innovations and future trends.
Antiviral Drug Discovery and Development
Language: en
Pages: 357
Authors: Xinyong Liu, Peng Zhan, Luis Menéndez-Arias, Vasanthanathan Poongavanam
Categories: Medical
Type: BOOK - Published: 2021-08-19 - Publisher: Springer

This book summarizes state-of-the-art antiviral drug design and discovery approaches starting from natural products to de novo design, and provides a timely update on recently approved antiviral drugs and compounds in advanced clinical development. Special attention is paid to viral infections with a high impact on the world population or
Antiviral Drug Development
Language: en
Pages: 314
Authors: Erik De Clercq, Richard T. Walker
Categories: Medical
Type: BOOK - Published: 2012-12-06 - Publisher: Springer Science & Business Media

Books about Antiviral Drug Development
Successful Strategies for the Discovery of Antiviral Drugs
Language: en
Pages: 534
Authors: Manoj C. Desai, Nicholas A. Meanwell, David E. Thurston
Categories: Medical
Type: BOOK - Published: 2013 - Publisher: Royal Society of Chemistry

A volume that will be aimed at medicinal chemistry and emerging drug discovery scientists. The book will be organized according to the various strategies deployed for the discovery and optimization of initial lead compounds. It will be broken down into four main sections: phenotypic and biochemical screening, structure and physical
Antiviral Drug Strategies
Language: en
Pages: 426
Authors: Erik De Clercq
Categories: Medical
Type: BOOK - Published: 2011-04-08 - Publisher: John Wiley & Sons

By focusing on general molecular mechanisms of antiviral drugs rather than therapies for individual viruses, this ready reference provides the critical knowledge needed to develop entirely novel therapeutics and to target new viruses. It begins with a general discussion of antiviral strategies, followed by a broad survey of known viral
Antiviral Drugs
Language: en
Pages: 472
Authors: Wieslaw M. Kazmierski
Categories: Medical
Type: BOOK - Published: 2011-07-08 - Publisher: John Wiley & Sons

This book focuses on new small molecule approaches to combat viral infections. The chapters describe the discovery and development from bench through the clinic of relatively recently-approved antiviral drugs and compounds in advanced clinical development. Organized by a virus (such as HIV, HCV, RSV, influenza, HBV and CMV) and written