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A collection of dramatic true crime stories includes the tale of a woman and two men caught up in an explosive love triangle that leads to obsession and murder in a small midwestern town. Original.
"Benjamin Peirce was one of the leading American scientists of the nineteenth century. This book tells the story of Peirce's life, but goes well beyond the biography of a mathematician. It includes information on the development of science and the emergence of colleges and universities in the United States during Peirce's adult life. It also deals with contemporary attitudes toward race and feminism, which form a contribution to social history, The author draws heavily upon diverse manuscript sources to tell Peirce's story."--BOOK JACKET.
Get a quick, expert overview of the many key facets of heart failure research with this concise, practical resource by Dr. Longjian Liu. This easy-to-read reference focuses on the incidence, distribution, and possible control of this significant clinical and public health problem which is often associated with higher mortality and morbidity, as well as increased healthcare expenditures. This practical resource brings you up to date with what’s new in the field and how it can benefit your patients. Features a wealth of information on epidemiology and research methods related to heart failure. Discusses pathophysiology and risk profile of heart failure, research and design, biostatistical basis of inference in heart failure study, advanced biostatistics and epidemiology applied in heart failure study, and precision medicine and areas of future research. Consolidates today’s available information and guidance in this timely area into one convenient resource.
Heart Failure in the Child and Young Adult: From Bench to Bedside combines multiple etiologies for pediatric heart failure, including congenital heart disease, cardiomyopathies, infectious diseases and metabolic abnormalities. This comprehensive resource combines research from multiple contributors with current guidelines to bridge the knowledge gap for the recognition and management of heart failure in children. Coverage begins with the basic science of heart failure, then progresses through diagnosis, management, treatment and surgery, finally concluding with advanced special topics, including genetics, self-management and nanomedicine. Provides coverage of the basic science of heart failure, its epidemiology and economic aspects, outpatient and inpatient management, and advanced therapies, including mechanical circulatory support and heart transplantation Combines cutting-edge research with current guidelines from the field
This book is a true account of the events on a long ago night when two angels from heaven "visited" me. It is the story of that "angelic encounter" as I experienced it. It happened many years ago, but the impressions are still vivid in my memory. It was not a fleeting glimpse of ethereal beings clothed in cloudy mist. Those angels were "real." If seen from a distance they probably would have seemed like ordinary men. Close up, however, no one could have mistaken them for men. Anyone would have known they were angels who had come down from heaven. During their first appearance, it seemed to me their speech to me lasted a long time. In retrospect that time period probably could have been measured in minutes. That is true even though they seemed like very "long" minutes. They were silent during their brief second appearance; albeit puzzled and inquisitive. These angels had about them a mysterious air of another world. They stood in front of my chair, in my living room with an indescribable and lofty majesty. Their posture and demeanor "spoke" of another sphere of existence. A sphere about which writers have speculated for thousands of years. They somehow "reeked" of an indescribable physical and mental power that was beyond my comprehension. My initial reaction was fright. A fright so great it overwhelmed my senses. I thought they had come to kill me. That was a certainty in my numbed mind. That fear quickly became life threatening. I did not know it at the time but their actions and speech would be forever impressed on my memory. During their first visit, they were extremely anxious to reassure me. They did not wish me to fear them. Their speech was sympathetic and reassuring. They told me they had not come to injure me in any way. They then explained the reason for their "intrusion" into my presence. Nothing that I have found anywhere in literature, except perhaps the bible, tells a similar story. My personality underwent a complete change that night. The brief account of that experience is now told for the first time in the 40 years since that encounter.
Whenever the heart is challenged with an increased work load for a prolonged period, it responds by increasing its muscle mass--a phenomenon known as cardiac hypertrophy. Although cardiac hypertrophy is commonly seen under physiological conditions such as development and exercise, a wide variety of pathological situa tions such as hypertension (pressure overload), valvular defects (volume overload), myocardial infarction (muscle loss), and cardiomyopathy (muscle disease) are also known to result in cardiac hypertrophy. Various hormones such as catecholamines, thyroid hormones, angiotensin II, endothelin, and growth factors have also been shown to induce cardiac hypertrophy. Although the exact mechanisms underlying or pathological forrns of cardiac hypertrophy are poorly under the physiological stood, an increase in the intraventricular pressure is believed to represent the major stimulus for the development of cardiac hypertrophy. In this regard, stretching of the cardiac muscle has been shown to induce the hypertrophic response, but the role of metabolic influences in this process cannot be ruled out. Furthermore, different hormones and other interventions in the absence of stretch have been observed to stimulate protein synthesis in both isolated cardiomyocyte and vascular myocyte preparations. Nonetheless, it is becoming dear that receptor as well as phospholipid linked signal transduction pathways are activated in some specific manner depend ing upon the initial hypertrophic stimulus, and these then result in an increase in the size and mass of cardiomyocytes.

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