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This book constitutes the refereed proceedings of the 10th International Conference on Integer Programming and Combinatorial Optimization, IPCO 2004, held in New York City, USA in June 2004. The 32 revised papers presented were carefully reviewed and selected from 109 submissions. Among the topics addressed are vehicle routing, network management, mixed-integer programming, computational complexity, game theory, supply chain management, stochastic optimization problems, production scheduling, graph computations, computational graph theory, separation algorithms, local search, linear optimization, integer programming, graph coloring, packing, combinatorial optimization, routing, flow algorithms, 0/1 polytopes, and polyhedra.