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This volume contains a collection of innovative techniques for studying targeted protein degradation. Chapters guide readers through heterobifunctional proteolysis-targeting chimeras (PROTACs) approaches, E3 ligase, E3 ligase-induced ubiquitylation, proteomic approaches, novel degrader molecules, molecular glue, and stabilize binding interaction between a target and E3 ubiquitin ligase. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Targeted Protein Degradation: Methods and Protocols aims to ensure successful results in this emerging field of drug discovery.
Targeted Protein Degradation
Language: en
Pages: 351
Authors: Angela M. Cacace, Christopher M. Hickey, Miklós Békés
Categories: Science
Type: BOOK - Published: 2021-08-26 - Publisher: Humana

This volume contains a collection of innovative techniques for studying targeted protein degradation. Chapters guide readers through heterobifunctional proteolysis-targeting chimeras (PROTACs) approaches, E3 ligase, E3 ligase-induced ubiquitylation, proteomic approaches, novel degrader molecules, molecular glue, and stabilize binding interaction between a target and E3 ubiquitin ligase. Written in the format of
Inducing Targeted Protein Degradation - FromChemical Biology to Drug Discovery and ClinicalApplications
Language: en
Pages: 350
Authors: P. Cromm
Categories: Science
Type: BOOK - Published: 2023-05-24 - Publisher: VCH

Books about Inducing Targeted Protein Degradation - FromChemical Biology to Drug Discovery and ClinicalApplications
Bactacs
Language: en
Pages:
Authors: Glen Brodie
Categories: Science
Type: BOOK - Published: 2020 - Publisher:

Books about Bactacs
Boc3Arg-linked Ligands Induce Degradation by Localizing Target Proteins to the 20s Proteasome
Language: en
Pages: 218
Authors: Yuntao Shi
Categories: Biodegradation
Type: BOOK - Published: 2017 - Publisher:

Targeted protein degradation is a promising strategy in therapeutics. Several small molecule approaches have been developed that cause target proteins to be degraded by the 26S proteasome. Such methods include ubiquitination, chaperones, and the 26S proteasome. Our laboratory also discovered that a recognition ligand linked to tert-butyl carbamate-protected arginine (Boc
Protein Degradation
Language: en
Pages: 393
Authors: R. John Mayer, Aaron J. Ciechanover, Martin Rechsteiner
Categories: Science
Type: BOOK - Published: 2005-04-15 - Publisher: Wiley-VCH

Annotation. The second volume in a new series dedicated to protein degradation, this book discusses the mechanism and cellular functions of targeted protein breakdown via the ubiquitin pathway. Drawing on the combined knowledge of the world's leading protein degradation experts, this handy reference compiles information on the proteasome-mediated degradation steps