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All fluid flow problems in the human body involve interaction with the vessel wall. This volume presents a number of studies where primarily mathematical modelling has been applied to a variety of medical wall-fluid interaction problems. The medical applications discussed are highly varied, while some key clinical areas are also addressed. Unusually, a number of important medical challenges involving fluid flow are considered in combination with the relevant solid mechanics. The complexity of addressing combined fluid flow and solid behaviour is viewed positively by the book’s distinguished contributors. For the researcher it offers new scope for developing and demonstrating a mastery of the scientific principles involved.
This authoritative book presents the basic knowledge and state-of-the-art techniques necessary to carry out investigations of the cardiovascular system using modeling and simulation. This volume contains chapters on anatomy, physiology, continuum mechanics, as well as pathological changes in the vasculature walls including the heart and their treatments. Methods of numerical simulations are given and illustrated in particular by application to wall diseases.
This volume in the series Lecture Notes in Computational Science and Engineering presents a collection of papers presented at the International Workshop on FSI, held in October 2005 in Hohenwart and organized by DFG's Research Unit 493 "FSI: Modeling, Simulation, and Optimization". The papers address partitioned and monolithic coupling approaches, methodical issues and applications, and discuss FSI from the mathematical, informatics, and engineering points of view.
This title discusses the anatomy and physiology of human respiration, some of the newest macro- and microscopic models of the respiratory system, numerical simulation and computer visualization of gas transport phenomena, and applications of these models to medical diagnostics, treatment and safety.
Leukocytes play an integral role in the pathogenesis of different inflammatory disorders. Recent results indicate that leukocytes are also involved in conditions that had not formerly been associated with a cytotoxic effect by leukocytes. In 27 chapters by leading investigators, this book reviews recent research on leukocyte adhesion and microvascular kinetics. Detailed descriptions of adhesive glycoproteins expressed on the surface of leukocytes and endothelial cells are given together with summaries of the current state of leukocyte rheology, kinetics and entrapment in microvessels. Since leukocytes reach all organs, the mechanisms described in this volume may apply to a wide range of cardiovascular disorders. A variety of important inflammatory and circulatory disorders are discussed including cerebral and coronary ischemia, shock, atherogenesis, chronic venous insufficiency, gastric ulcer and diabetic retinopathy. New concepts about the etiology of cardiovascular complications are presented, with emphasis on molecular, cellular, and microvascular mechanisms. The current state of endogenous anti-adhesive and pro-adhesive mediators is summarized, including interventions against leukocyte activation and adhesion.
Dealing with the field of biomechanics, this book covers topics including dynamics of musculoskeletal systems, mechanics of hard and soft tissues, mechanics of bone remodeling, mechanics of blood and air flow, flow-prosthesis interfaces, mechanics of impact, and, dynamics of man-machine interaction.
Intended as a review, rather than a detailed description of the theories involved, this title provides a general introduction together with appropriate references. Topics covered include: Nanotechnology; The Ultrastructural and Functional Basis of Nanoscale Transport Phenomena in Physiology; Transport of Macromolecules Across the Arterial Wall and its Relevance to Atherogenesis, and Other Issues in Blood-Wall Interaction; Transport Phenomena in the Cell; and Computational Methods for Nanoscale Fluid Flow Problems. Over 2,000 references are included.
This book offers a mathematical update of the state of the art of the research in the field of mathematical and numerical models of the circulatory system. It is structured into different chapters, written by outstanding experts in the field. Many fundamental issues are considered, such as: the mathematical representation of vascular geometries extracted from medical images, modelling blood rheology and the complex multilayer structure of the vascular tissue, and its possible pathologies, the mechanical and chemical interaction between blood and vascular walls, and the different scales coupling local and systemic dynamics. All of these topics introduce challenging mathematical and numerical problems, demanding for advanced analysis and efficient simulation techniques, and pay constant attention to applications of relevant clinical interest. This book is addressed to graduate students and researchers in the field of bioengineering, applied mathematics and medicine, wishing to engage themselves in the fascinating task of modeling the cardiovascular system or, more broadly, physiological flows.
Free surface flows arise in the natural world, physical and biological sciences and in some areas of modern technology and engineering. Exam ples include the breaking of sea waves on a harbour wall, the transport of sloshing fluids in partly filled containers, and the design of micronozzles for high speed ink-jet printing. Apart from the intrinsic mathematical challenge in describing and solving the governing equations, there are usually important environmental, safety and engineering features which need to be analysed and controlled. A rich variety of techniques has been developed over the past two decades to facilitate this analysis; singular perturbations, dynamical systems, and the development of sophisticated numerical codes. The extreme and sometimes violent nature of some free surface flows taxes these methods to the limit. The work presented at the symposium addressed these limits and can be loosely classified into four areas: (i) Axisymmetric free surface flows. There are a variety of problems in the printing, glass, fertiliser and fine chemical industries in which threads of fluid are made and controlled. Presentations were made in the areas of pinch-off for inviscid and viscous threads of fluid, recoil effects after droplet formation and the control of instability by forced vibration. (ii) Dynamic wetting. The motion of three phase contact lines, which are formed at the junction between two fluids and a solid, plays an important role in fluid mechanics.
Medical Physiology, in its updated 2nd edition, firmly relates molecular and cellular biology to the study of human physiology and disease. Drs. Walter Boron and Emile Boulpaep and a team of leading physiologists present you with practical, accurate coverage, continually emphasizing the clinical implications of the material. Each chapter explains the principles and organization of each body system, while more than 1400 high-quality, full-color line drawings and prominently featured clinical examples clarify every concept. This exceptionally detailed and comprehensive guide to physiology is ideal for a rich, straightforward, state-of-the-art understanding of this essential subject. Quickly review important content using prominent boxes included throughout the text to provide clinical examples of disordered physiology. Master difficult concepts with the use of 800 color drawings that feature balloon captions explaining key processes. Find information easily with the intuitive organization by body system and consistent style. Get up-to-date coverage of physiology with updated text and figures. Access the fully searchable text online at, along with Webnotes, Image Bank, 150 Self-assessment questions, and 10 physiology animations. Stay current thanks to updated material, including a new chapter on Physiology of Aging and a new section on hemostasis. Gain a clear visual understanding with a revised and updated art program of high-quality, full color line drawings and prominently featured clinical examples.
Realizing the need of interaction between universities and research groups in industry, the European Consortium for Mathematics in Industry (ECMI) was founded in 1986 by mathematicians from ten European universities. Since then it has been continuously extending and now it involves about all Euro pean countries. The aims of ECMI are • To promote the use of mathematical models in industry. • To educate industrial mathematicians to meet the growing demand for such experts. • To operate on a European Scale. Mathematics, as the language of the sciences, has always played an im portant role in technology, and now is applied also to a variety of problems in commerce and the environment. European industry is increasingly becoming dependent on high technology and the need for mathematical expertise in both research and development can only grow. These new demands on mathematics have stimulated academic interest in Industrial Mathematics and many mathematical groups world-wide are committed to interaction with industry as part of their research activities. ECMI was founded with the intention of offering its collective knowledge and expertise to European Industry. The experience of ECMI members is that similar technical problems are encountered by different companies in different countries. It is also true that the same mathematical expertise may often be used in differing industrial applications.
This book focuses on the most recent advances in the application of visualization and simulation methods to understand the flow behavior of complex fluids used in biomedical engineering and other related fields. It shows the physiological flow behavior in large arteries, microcirculation, respiratory systems and in biomedical microdevices.
Cardiovascular Physiological Processes—Advances in Research and Application: 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Cardiovascular Physiological Processes in a compact format. The editors have built Cardiovascular Physiological Processes—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Cardiovascular Physiological Processes in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Cardiovascular Physiological Processes—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at
This book surveys research results on the physical and mathematical modeling, as well as the numerical simulation of complex fluid and structural mechanical processes occurring in the human blood circulation system. Topics treated include continuum mechanical description; choice of suitable liquid and wall models; mathematical analysis of coupled models; numerical methods for flow simulation; parameter identification and model calibration; fluid-solid interaction; mathematical analysis of piping systems; particle transport in channels and pipes; artificial boundary conditions, and many more. The book was developed from lectures presented by the authors at the Oberwolfach Research Institute (MFO), in Oberwolfach-Walke, Germany, November, 2005.
Part medicine, part biology, and part engineering, biomedicine and bioengineering are by their nature hybrid disciplines. To make these disciplines work, engineers need to speak "medicine," and clinicians and scientists need to speak "engineering." Building a bridge between these two worlds, Biofluid Mechanics: The Human Circulation integrates fluid and solid mechanics relationships and cardiovascular physiology. The book focuses on blood rheology, steady and unsteady flow models in the arterial circulation, and fluid mechanics through native heart valves. The authors delineate the relationship between fluid mechanics and the development of arterial diseases in the coronary, carotid, and ileo-femoral arteries. They go on to elucidate methods used to evaluate the design of circulatory implants such as artificial heart valves, stents, and vascular grafts. The book covers design requirements for the development of an ideal artificial valve, including a discussion of the currently available mechanical and bioprosthetic valves. It concludes with a detailed description of common fluid mechanical measurements used for diagnosing arterial and valvular diseases as well as research studies that examine the possible interactions between hemodynamics and arterial disease. Drawing on a wide range of material, the authors cover both theory and practical applications. The book breaks down fluid mechanics into key definitions and specific properties and then uses these pieces to construct a solid foundation for analyzing biofluid mechanics in both normal and diseased conditions.
Mathematical models and numerical simulations can aid the understanding of physiological and pathological processes. This book offers a mathematically sound and up-to-date foundation to the training of researchers and serves as a useful reference for the development of mathematical models and numerical simulation codes.
Supported with 140 illustrations, the volume exhaustively covers the micro- and nano-system technologies involved in developing cell-based bioengineering applications. You get full details on efforts to engineer the soluble and insoluble cell microenvironments, including the latest advances in microfluidic devices, surface patterning, 3D scaffolds, and techniques for engineering cellular mechanical properties and topography.
The book presents the state of the art in the interdisciplinary field of fluid mechanics applied to cardiovascular modelling. It is neither a monograph nor a collection of research papers, rather an extended review in the field. It is arranged in 4 scientific chapters each presenting thoroughly the approach of a leading research team; two additional chapters prepared by biomedical scientists present the topic by the applied perspective. A unique feature is a substantial (approx. one fourth of the book) medical introductory part, written by clinical researchers for scientific readers, that would require a large effort to be collected otherwise.

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